3,4-diamino-N-(6-trifluoromethylpyridin-3-yl)-benzamide → 3-{3,5-Dichloro-4-[6-(6-trifluoromethylpyridin-3-ylcarbamoyl)-1H-benzoimidazol-2-yl]-phenyl}-propionic acid

Participants

Reaction Steps

The title compound was prepared from 3,4-diamino-N-(6-trifluoromethylpyridin-3-yl)-benzamide (from Example 6-36) and 3-(3,5-dichloro-4-formylphenyl)-propionic acid tert butyl ester analogous to Example 6-25. 1H NMR (MeOD, 400 MHz): δ 9.07 (d, 1H), 8.54 (dd, 1H), 8.35 (s, 1H), 7.99 (dd, 1H), 7.84 (dd, 1H), 7.76 (d, 1H), 7.52 (s, 2H), 3.01 (t, 2H), 2.69 (t, 2H); MS (m/z) 523.01 (M+1), Retention time=1.06 min (Method 10).

Provenance & Evidence