反应详情

温度

80 °C

10.00 kg (33.82 mol) (Z)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-methoxy-acrylic acid (C) were suspended in 20.0 L acetic acid and heated to 80° C., before 57.02 kg (338.25 mol) hydrobromic acid (48%) were added. Then the reaction mixture was stirred for 1.5 hours at 80° C., then diluted with 78.0 L water and the suspension was cooled to 22° C. The product was separated off, washed with 100.0 L water and dried.

1. additionwere added
2. temperaturethe suspension was cooled to 22° C
3. customThe product was separated off
4. washwashed with 100.0 L water
5. customdried