Formic Acid → HCID 67058145, compound

HRID 1515116Notes

Reaction equation

HRID 1515116 reaction equation
C(O)=O.C(N(CC)CC)C.[F:11][C:12]([F:24])([F:23])[C:13]1[C:21]2[O:20][CH2:19][C:18](=[O:22])[C:17]=2[CH:16]=[CH:15][CH:14]=1>ClCCl>[F:24][C:12]([F:11])([F:23])[C:13]1[C:21]2[O:20][CH2:19][C@H:18]([OH:22])[C:17]=2[CH:16]=[CH:15][CH:14]=1

Participants

5

Reactant 3

HCID 284Formic AcidHCID 8471TriethylamineHCID 67058170HCID 67058170, compound

Product 1

HCID 67058145HCID 67058145, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a mixture of formic acid (60 μL, 1.56 mmol) and triethylamine (186 μL, 1.33 mmol), a dichloromethane (2.0 mL) solution of 7-(trifluoromethyl)-1-benzofuran-3-one (90 mg, 0.445 mmol) produced in Example 47 (47E) was added, and chloro[(1S,2S)—N-(p-toluenesulfonyl)-1,2-diphenylethanediamine](mesitylene)ruthenium(II) (8.4 mg, 0.013 mmol) was added thereto at room temperature, and then, the resulting mixture was stirred overnight under a nitrogen atmosphere at room temperature.

Sources & evidence

ORD record
ord-5939e897b5cf4a58b8c390703683eb1c
Source dataset
uspto-grants-2012_07
Patent number
US08222281B2

Reaction notes

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