反应详情

A stirred mixture of (2-aminophenyl)(1-methylpiperidin-4-yl)methanone (1.10 g, 4.58 mmol), urea (550 mg, 9.17 mmol) and acetic acid (15 mL) was heated to overnight. The mixture was cooled to rt, neutralized with 1 N sodium hydroxide and concentrated to ˜10 mL on a rotary evaporator. The aqueous residue was extracted with ethyl acetate and the combined organics were dried over sodium sulfate, filtered and concentrated on a rotary evaporator to afford 4-(1-methylpiperidin-4-yl)quinazolin-2(1H)-one as a yellow solid (1.10 g, 97%).

1. temperaturewas heated to overnight
2. concentrationconcentrated to ˜10 mL on a rotary evaporator
3. extractionThe aqueous residue was extracted with ethyl acetate
4. dry with materialthe combined organics were dried over sodium sulfate
5. filtrationfiltered
6. concentrationconcentrated on a rotary evaporator