反应详情

To a well stirred solution of 2-chloro-5-hydroxymethyl-benzenesulfonamide (31.6 g, 143 mmol) in 300 mL tetrahydrofuran is added 62.0 g (713 mmol) of MnO2. The resulting solution is heated at reflux for 16 h, filtered through Celite then through a 0.4 μM Teflon filter and the filtrate is concentrated in vacuo to remove the tetrahydrofuran. Trituration with hexanes provided 25 g (80%) of the title compound as a grey solid.

1. temperatureThe resulting solution is heated
2. temperatureat reflux for 16 h
3. filtrationfiltered through Celite
4. filtrationthrough a 0.4 μM Teflon filter
5. concentrationthe filtrate is concentrated in vacuo
6. customto remove the tetrahydrofuran