HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-Dimethoxyphenylboronic acid → 2-(3,4-Dimethoxyphenyl)-2-(1,3-dioxoisoindolin-5-ylamino)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-Dimethoxyphenylboronic acid | HCID 2734702 | — |
| Reactant | Glyoxylic acid, monohydrate | HCID 15620607 | — |
| Reactant | 2-(3-Carbamoyl-4-fluorophenylamino)-2-(3,4-dimethoxyphenyl)acetic acid | HCID 59479392 | — |
| Reactant | HCID 68106733 | HCID 68106733 | — |
| Product | 2-(3,4-Dimethoxyphenyl)-2-(1,3-dioxoisoindolin-5-ylamino)acetic acid | HCID 59479470 | 88% |
Reaction Steps
17A was prepared in a procedure similar to that of 13A using 5-iminoisoindoline-1,3-dione, 3,4-dimethoxyphenylboronic acid and glyoxylic acid monohydrate. Yield: 88%. 1H NMR (400 MHz, Methanol-d4) δ ppm 3.82 (s, 3H) 3.83 (s, 3H) 5.17 (s, 1H) 6.90 (dd, J=8.35, 2.20 Hz, 1H) 6.95 (d, J=7.91 Hz, 1H) 6.99 (d, J=2.20 Hz, 1H) 7.07-7.10 (m, 1H) 7.13 (d, J=2.20 Hz, 1H) 7.50 (d, J=8.35 Hz, 1H), LCMS: 366 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08222453B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-881bd93e3a2f4ff7809bc5c5a5667866 |
| Source note | uspto-grants-2012_07 |