HuagongsheHuagongshe Chemistry Print Report · For research reference only
Glyoxylic acid, monohydrate → 2-(5-Carbamoyl-2-fluorophenylamino)-2-(4-chloro-3-methoxyphenyl)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Glyoxylic acid, monohydrate | HCID 15620607 | — |
| Reactant | 3-Amino-4-fluorobenzamide | HCID 16782100 | — |
| Reactant | (4-Chloro-3-methoxyphenyl)boronic acid | HCID 23005377 | — |
| Reactant | 2-(3-Carbamoylphenylamino)-2-(3,4-dimethoxyphenyl)acetic acid | HCID 59838034 | — |
| Product | 2-(5-Carbamoyl-2-fluorophenylamino)-2-(4-chloro-3-methoxyphenyl)acetic acid | HCID 59479421 | 37% |
Reaction Steps
25B was prepared in a procedure similar to that of 1A using 25A, 19B and glyoxylic acid monohydrate. Yield: 37%. 1H NMR (400 MHz, Methanol-d4) δ ppm 3.88 (s, 3H) 5.21 (s, 1H) 7.03-7.12 (m, 3H) 7.13-7.19 (m, 1H) 7.25 (d, J=1.76 Hz, 1H) 7.33 (d, J=7.91 Hz, 1H), LCMS: 353 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08222453B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-50ffb40bb3e44f0594888b01a9be3601 |
| Source note | uspto-grants-2012_07 |