HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
5-Amino-2-fluorobenzamide → 2-(3-Carbamoyl-4-fluorophenylamino)-2-(4-fluoro-3-methoxyphenyl)acetic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 5-Amino-2-fluorobenzamide | HCID 2778899 | — |
| Edukt | Glyoxylic acid, monohydrate | HCID 15620607 | — |
| Edukt | (4-Fluoro-3-methoxyphenyl)boronic acid | HCID 44558185 | — |
| Edukt | 2-(3-Carbamoylphenylamino)-2-(3,4-dimethoxyphenyl)acetic acid | HCID 59838034 | — |
| Produkt | 2-(3-Carbamoyl-4-fluorophenylamino)-2-(4-fluoro-3-methoxyphenyl)acetic acid | HCID 59479452 | 43% |
Reaktionsschritte
39A was prepared in a procedure similar to that of 1A using 3-amino-6-fluorobenzamide, 7C and glyoxylic acid monohydrate. Yield: 43%. 1H NMR (400 MHz, Methanol-d4) δ ppm 3.85 (s, 3H) 5.05 (s, 1H) 6.75-6.82 (m, 1H) 6.92-6.97 (m, 1H) 7.03-7.08 (m, 3H) 7.24-7.29 (m, 1H), LCMS: 337 (M+1).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08222453B2 |
| Quelldatensatz | uspto-grants-2012_07 |
| ORD ID | ord-bf8887147a0847b093cac9578fb8264e |
| Quellennotiz | uspto-grants-2012_07 |