HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-Dimethoxyphenylboronic acid → 2-(3-Carbamoyl-5-methoxyphenylamino)-2-(3,4-dimethoxyphenyl)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-Dimethoxyphenylboronic acid | HCID 2734702 | — |
| Reactant | Glyoxylic acid, monohydrate | HCID 15620607 | — |
| Reactant | 2-(3-Carbamoyl-5-methylphenylamino)-2-(3,4-dimethoxyphenyl)acetic acid | HCID 59479497 | — |
| Reactant | 3-Amino-5-methoxybenzamide | HCID 59479527 | — |
| Product | 2-(3-Carbamoyl-5-methoxyphenylamino)-2-(3,4-dimethoxyphenyl)acetic acid | HCID 59479457 | — |
Reaction Steps
Using a procedure analogous to that described for the preparation of 89D, 93D was reacted with 3,4-dimethoxyphenylboronic acid and glyoxylic acid monohydrate to give 93E. 1H NMR (400 MHz, CD3OD) δ ppm 3.73 (s, 3H) 3.80 (s, 3H) 3.81 (s, 3H) 5.07 (s, 1H) 6.39 (t, J=1.98 Hz, 1H) 6.75 (s, 1H) 6.81 (s, 1H) 6.92 (d, J=8.35 Hz, 1H) 7.07 (dd, J=8.35, 1.76 Hz, 1H) 7.11 (d, J=1.76 Hz, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08222453B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-3f635167ec794e4292b12fbe4ef5a9c2 |
| Source note | uspto-grants-2012_07 |