HRID1515567

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID15620607

Oxoacetic acid--water (1/1)

C2H4O4

HCID16782100

3-Amino-4-fluorobenzamide

C7H7FN2O

HCID59479435

B-(3-Ethyl-4-fluorophenyl)boronic acid

C8H10BFO2

结构：COc1ccc(C(Nc2cccc(C(N)=O)c2)C(=O)O)cc1OC

HCID59838034

未命名化合物

PRODUCTS

生成物

结构：CCc1cc(C(Nc2cc(C(N)=O)ccc2F)C(=O)O)ccc1F

HCID59479458

α-[[5-(Aminocarbonyl)-2-fluorophenyl]amino]-3-ethyl-4-fluorobenzeneacetic acid

C17H16F2N2O3

收率 48%

PROCEDURE

实验过程

95C was prepared in a procedure similar to that of 1A using 19B, 95B and glyoxylic acid monohydrate. Yield: 48%. 1H NMR (400 MHz, Methanol-d4) δ ppm 1.19 (t, J=7.69 Hz, 3H) 2.65 (q, J=7.47 Hz, 2H) 5.18 (s, 1H) 6.98-7.11 (m, 3 H) 7.12-7.18 (m, 1H) 7.31-7.38 (m, 1H) 7.40-7.45 (m, 1H); LCMS: 335 (M+1).