HuagongsheHuagongshe Chemistry Print Report · For research reference only
Glyoxylic acid, monohydrate → 2-(5-Carbamoyl-2-fluorophenylamino)-2-(3-ethyl-4-fluorophenyl)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Glyoxylic acid, monohydrate | HCID 15620607 | — |
| Reactant | 3-Amino-4-fluorobenzamide | HCID 16782100 | — |
| Reactant | 3-Ethyl-4-fluorophenylboronic acid | HCID 59479435 | — |
| Reactant | 2-(3-Carbamoylphenylamino)-2-(3,4-dimethoxyphenyl)acetic acid | HCID 59838034 | — |
| Product | 2-(5-Carbamoyl-2-fluorophenylamino)-2-(3-ethyl-4-fluorophenyl)acetic acid | HCID 59479458 | 48% |
Reaction Steps
95C was prepared in a procedure similar to that of 1A using 19B, 95B and glyoxylic acid monohydrate. Yield: 48%. 1H NMR (400 MHz, Methanol-d4) δ ppm 1.19 (t, J=7.69 Hz, 3H) 2.65 (q, J=7.47 Hz, 2H) 5.18 (s, 1H) 6.98-7.11 (m, 3 H) 7.12-7.18 (m, 1H) 7.31-7.38 (m, 1H) 7.40-7.45 (m, 1H); LCMS: 335 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08222453B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-e9737156df23478a85b71f8f5159c6ad |
| Source note | uspto-grants-2012_07 |