3-Pyridinecarboxamide, 5-amino- → 2-(5-Carbamoylpyridin-3-ylamino)-2-(3,4-dimethoxyphenyl)acetic acid

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	3-Pyridinecarboxamide, 5-amino-	HCID 173747	—
Edukt	3,4-Dimethoxyphenylboronic acid	HCID 2734702	—
Edukt	Glyoxylic acid, monohydrate	HCID 15620607	—
Edukt	2-(3-Carbamoyl-4-fluorophenylamino)-2-(3,4-dimethoxyphenyl)acetic acid	HCID 59479392	—
Produkt	2-(5-Carbamoylpyridin-3-ylamino)-2-(3,4-dimethoxyphenyl)acetic acid	HCID 59479403	63%

Reaktionsschritte

97C was prepared in a procedure similar to that of 13A using 97B, 3,4-dimethoxyphenylboronic acid and glyoxylic acid monohydrate. Yield: 63%. 1H NMR (400 MHz, Methanol-d4) δ ppm 3.82 (s, 3H) 3.84 (s, 3H) 5.28 (s, 1H) 6.97 (d, J=8.35 Hz, 1H) 7.08 (s, 1H) 7.13 (d, J=2.20 Hz, 1H) 8.14 (s, 2H) 8.38 (s, 1H); LCMS: 331 (M+1).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08222453B2
Quelldatensatz	uspto-grants-2012_07
ORD ID	ord-d91653a2ef4e41e0af49fb3059939872
Quellennotiz	uspto-grants-2012_07