反应详情

温度

0 °C

To a solution of (tetrahydro-pyran-2-yl)-acetic acid ethyl ester (77.1 g, 0.45 mol) in tetrahydrofuran (1.5 L) at 0° C. was added lithium aluminium hydride (22.1 g, 0.58 mol) in several portions. The mixture was stirred at 0° C. for 2 h and quenched with 1 N sodium hydroxide solution. The mixture was filtered and the filter cake was washed with dichloromethane (4×300 mL). The combined organic layers were concentrated in vacuo. The crude product was purified by distillation under reduced pressure to afford 2-(tetrahydro-pyran-2-yl)-ethanol (53.5 g, 92% yield) as a colorless oil.

1. customquenched with 1 N sodium hydroxide solution
2. filtrationThe mixture was filtered
3. washthe filter cake was washed with dichloromethane (4×300 mL)
4. concentrationThe combined organic layers were concentrated in vacuo
5. distillationThe crude product was purified by distillation under reduced pressure