反应详情

4-(4-Methylphenyl)butanol (0.5 g, 3.04 mmol) is dissolved in 5 ml DMF and to it is added imidazole (310 mg, 4.56 mmol) and tert-butyldimethylsilyl chloride (685 mg, 4.56 mmol). The reaction is stirred for 4 hrs after which it is extracted in ethyl acetate and washed with water to remove all DMF. The organic layer is then dried and concentrated. The crude mixture is then purified by flash chromatography using a mixture of ethyl acetate-hexanes as the eluting medium to afford the above mentioned product.

1. extractionis extracted in ethyl acetate
2. washwashed with water
3. customto remove all DMF
4. customThe organic layer is then dried
5. concentrationconcentrated
6. customThe crude mixture is then purified by flash chromatography
7. additiona mixture of ethyl acetate-hexanes as the eluting medium
8. customto afford the