Hydrazine hydrate (1:1) → HCID 178514432, compound

HRID 1516156Notes

Reaction equation

HRID 1516156 reaction equation
C[O:2][C:3]([C@H:5]1[CH2:10][CH2:9][C@H:8]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:7][CH2:6]1)=O.O.[NH2:19][NH2:20]>>[O:11]([C@H:8]1[CH2:9][CH2:10][C@H:5]([C:3]([NH:19][NH2:20])=[O:2])[CH2:6][CH2:7]1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 178501257HCID 178501257, compound

Product 1

HCID 178514432HCID 178514432, compound

Conditions

Temperature
120 °C

Procedure

A mixture of trans-4-phenoxy-cyclohexanecarboxylic acid methyl ester (1.07 g, 4.57 mmol) and hydrazine hydrate (0.22 g, 4.48 mmol) was heated at 120° C. for 4 h. After cooling to room temperature the reaction mixture was concentrated in vacuo to give the crude title compound as white solid in quantitative yield, which was used in the next step without further purification.

Workup

  1. temperatureAfter cooling to room temperature the reaction mixture
  2. concentrationwas concentrated in vacuo

Sources & evidence

ORD record
ord-c8e9c8d73b7c4d04afb76377e71d9390
Source dataset
uspto-grants-2012_07
Patent number
US08227458B2

Reaction notes

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