HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridazine-3-carboxylic acid methyl ester → 6-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridazine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridazine-3-carboxylic acid methyl ester | HCID 66599092 | — |
| Reactant | 6-(3-Butyl-5-methyl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester | HCID 66599158 | — |
| Product | 6-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridazine-3-carboxylic acid | HCID 66598975 | 45.2% |
Reaction Steps
As described for example 10a, 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridazine-3-carboxylic acid methyl ester (960 mg, 2.95 mmol) was converted, instead of 6-(3-butyl-5-methyl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester, to the title compound (415 mg, 45%) which was obtained as a white solid. MS: m/e=310.1 [M−H]−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08227461B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-1096b26e4bae4099b1137fef9657e42b |
| Source note | uspto-grants-2012_07 |