Acetic Anhydride → HCID 16748464, compound

HRID 1516245Notes

Reaction equation

HRID 1516245 reaction equation
[F:1][C:2]([F:27])([F:26])[CH:3]1[CH2:8][CH2:7][C:6]([C:9]2[N:14]=[CH:13][N:12]=[C:11]([O:15][C:16]3[C:21]4[N:22]=[C:23]([NH2:25])[S:24][C:20]=4[CH:19]=[CH:18][CH:17]=3)[CH:10]=2)=[CH:5][CH2:4]1.[C:28](OC(=O)C)(=[O:30])[CH3:29]>C1(C)C=CC=CC=1>[F:27][C:2]([F:26])([F:1])[CH:3]1[CH2:8][CH2:7][C:6]([C:9]2[N:14]=[CH:13][N:12]=[C:11]([O:15][C:16]3[C:21]4[N:22]=[C:23]([NH:25][C:28](=[O:30])[CH3:29])[S:24][C:20]=4[CH:19]=[CH:18][CH:17]=3)[CH:10]=2)=[CH:5][CH2:4]1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 57681120HCID 57681120, compound

Product 1

HCID 16748464HCID 16748464, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
90 °C

Procedure

To a suspension of 4-[6-(4-trifluoromethyl-cyclohex-1-enyl)-pyrimidin-4-yloxy]-benzothiazol-2-ylamine, Example 1(e), (85 mg, 0.22 mmol) in toluene was added acetic anhydride (82 μL, 0.86 mmol). The mixture was heated at 90° C. with stirring for 1 h. The reaction mixture was allowed to cool to room temperature and evaporated in vacuo to give the title compound as a white solid. MS (ESI, pos. ion.) m/z: 435 (M+1).

Workup

  1. temperatureto cool to room temperature
  2. customevaporated in vacuo

Sources & evidence

ORD record
ord-4ad1c82cfa0e41f7b5fe57b2d933cf9c
Source dataset
uspto-grants-2012_07
Patent number
US08227469B2

Reaction notes

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