(S)-1-(1-(4-fluorophenyl)ethyl)piperazine → (6-{4-[(1S)-1-(4-Fluorophenyl)-ethyl]-piperazin-1-yl}-pyrimidin-4-yl)-quinolin-7-yl-amine

HRID 1516246노트

반응식

HRID 1516246 반응식
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]2[CH:18]=[C:17]3[C:12]([CH:13]=[CH:14][CH:15]=[N:16]3)=[CH:11][CH:10]=2)[CH:3]=1.[F:19][C:20]1[CH:25]=[CH:24][C:23]([C@@H:26]([N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)[CH3:27])=[CH:22][CH:21]=1>>[F:19][C:20]1[CH:25]=[CH:24][C:23]([C@@H:26]([N:28]2[CH2:29][CH2:30][N:31]([C:2]3[N:7]=[CH:6][N:5]=[C:4]([NH:8][C:9]4[CH:18]=[C:17]5[C:12]([CH:13]=[CH:14][CH:15]=[N:16]5)=[CH:11][CH:10]=4)[CH:3]=3)[CH2:32][CH2:33]2)[CH3:27])=[CH:22][CH:21]=1

참가 물질

3

반응물 2

HCID 16748802(S)-1-(1-(4-fluorophenyl)ethyl)piperazineHCID 22135502N-(6-chloro-4-pyrimidinyl)-7-Quinolinamine

생성물 1

HCID 57681119(6-{4-[(1S)-1-(4-Fluorophenyl)-ethyl]-piperazin-1-yl}-pyrimidin-4-yl)-quinolin-7-yl-amine

실험 절차

(6-Chloropyrimidin-4-yl)-quinolin-7-yl-amine, Example 4(c), (59 mg, 0.23 mmol) was reacted with 1-[(1S)-1-(4-fluorophenyl)ethyl]piperazine (57 mg, 0.27 mmol, prepared from (1S)-1-(4-fluorophenyl)ethylamine (SynQuest) according steps (a) and (b) of Example 4) under the conditions of Example 4(d) to give the title compound. M.p.: 206-207° C. MS (ESI, pos. ion.) m/z: 429 (M+1).

출처 및 근거

ORD 기록
ord-1b74e85ad8134eb1acf76d6e7babf60a
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08227469B2

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