HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-1-(1-(4-fluorophenyl)ethyl)piperazine → (6-{4-[(1S)-1-(4-Fluorophenyl)-ethyl]-piperazin-1-yl}-pyrimidin-4-yl)-quinolin-7-yl-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-1-(1-(4-fluorophenyl)ethyl)piperazine | HCID 16748802 | — |
| Reactant | N-(6-chloro-4-pyrimidinyl)-7-Quinolinamine | HCID 22135502 | — |
| Product | (6-{4-[(1S)-1-(4-Fluorophenyl)-ethyl]-piperazin-1-yl}-pyrimidin-4-yl)-quinolin-7-yl-amine | HCID 57681119 | — |
Reaction Steps
(6-Chloropyrimidin-4-yl)-quinolin-7-yl-amine, Example 4(c), (59 mg, 0.23 mmol) was reacted with 1-[(1S)-1-(4-fluorophenyl)ethyl]piperazine (57 mg, 0.27 mmol, prepared from (1S)-1-(4-fluorophenyl)ethylamine (SynQuest) according steps (a) and (b) of Example 4) under the conditions of Example 4(d) to give the title compound. M.p.: 206-207° C. MS (ESI, pos. ion.) m/z: 429 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08227469B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-1b74e85ad8134eb1acf76d6e7babf60a |
| Source note | uspto-grants-2012_07 |