Hydrochloric Acid → HCID 67281436, compound

HRID 1516329Notes

Reaction equation

HRID 1516329 reaction equation
[F:1][C:2]1[CH:34]=[CH:33][C:5]([C:6]([NH:8][C@H:9]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([N:19]4[CH2:24][CH2:23][N:22](C(OC(C)(C)C)=O)[CH2:21][CH2:20]4)[CH:17]=3)[CH2:12][CH2:11][C@@H:10]2[OH:32])=[O:7])=[CH:4][CH:3]=1.[ClH:35]>O1CCOCC1>[ClH:35].[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([NH:8][C@H:9]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([N:19]4[CH2:20][CH2:21][NH:22][CH2:23][CH2:24]4)[CH:17]=3)[CH2:12][CH2:11][C@@H:10]2[OH:32])=[O:7])=[CH:33][CH:34]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67281035HCID 67281035, compound

Product 1

HCID 67281436HCID 67281436, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Conditions

Temperature
50 °C

Procedure

To a solution of tert-butyl 4-[(3S,4S)-4-[(4-fluorobenzoyl)amino]-3-hydroxy-tetralin-6-yl]piperazine-1-carboxylate (19.4 g, 41.3 mmol) in 1,4-dioxane (430 mL) add 4 M hydrogen chloride in dioxane (135 mL) at room temperature. Stir the resulting slurry mechanically at 50° C. for 13 hr. Concentrate the reaction in vacuo to obtain the title compound (24.8 g, quantitative). LC-ES/MS m/z 370 [M+H]+.

Workup

  1. concentrationConcentrate
  2. customthe reaction in vacuo

Sources & evidence

ORD record
ord-be03374400b14bc88d3e0c9e8eed921a
Source dataset
uspto-grants-2012_07
Patent number
US08227468B2

Reaction notes

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