Hydrochloric Acid → HCID 68933384, compound

HRID 1516392Notes

Reaction equation

HRID 1516392 reaction equation
[CH3:1][N:2]([CH3:21])[C:3]1[N:8]=[CH:7][C:6]([NH:9]C(OC(C)(C)C)=O)=[C:5]([C:17]([F:20])([F:19])[F:18])[CH:4]=1.C(OCC)C.[ClH:27]>O1CCOCC1>[ClH:27].[CH3:1][N:2]([CH3:21])[C:3]1[N:8]=[CH:7][C:6]([NH2:9])=[C:5]([C:17]([F:20])([F:18])[F:19])[CH:4]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 68929718HCID 68929718, compound

Product 1

HCID 68933384HCID 68933384, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of 0.73 g (2.39 mmol) of 6-dimethylamino-4-trifluoromethyl-3-(tert-butoxycarbonylamino)pyridine, prepared in stage 10.3, in 8.5 ml of 4N hydrochloric acid in dioxane is stirred at reflux for 5 hours. 200 ml of ethyl ether are subsequently added to the cooled reaction mixture. 0.6 g of a precipitate is collected by filtration.

Workup

  1. temperatureat reflux for 5 hours
  2. filtration0.6 g of a precipitate is collected by filtration

Sources & evidence

ORD record
ord-7970038cd9644cda9dd22d700d5e8548
Source dataset
uspto-grants-2012_07
Patent number
US08227489B2

Reaction notes

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