反应详情

温度

0 °C

To a solution of 4-bromo-1-(2-methylsulfanyl-pyrimidin-4-yl)-1H-indole (5.0 g) in DCM (200 mL) at 0° C. was added MCPBA (4.01 g) in portions, and the mixture stirred at 0° C. for 1 h. The reaction mixture was quenched in 10% Na2SO3 (aq), partitioned between DCM and NaHCO3 (aq), the organic layer washed with NaHCO3 (aq), and dried over Na2SO4. The solvent was stripped to provide a light yellow solid, which was then treated with hot EtOAc/hexane (50:50), filtered, dried to provide 4-bromo-1-(2-methylsulfinyl-pyrimidin-4-yl)-1H-indole (4.98 g) as an off-white powder.

1. customThe reaction mixture was quenched in 10% Na2SO3 (aq)
2. custompartitioned between DCM and NaHCO3 (aq)
3. washthe organic layer washed with NaHCO3 (aq)
4. dry with materialdried over Na2SO4
5. customto provide a light yellow solid, which
6. filtrationfiltered
7. customdried