참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | m-Chloroperbenzoic acid | HCID 70297 | — |
| 반응물 | Ethyl acetate hexane | HCID 21226206 | — |
| 반응물 | 4-bromo-1-(2-(methylthio)pyrimidin-4-yl)-1H-indole | HCID 58137958 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4-bromo-1-(2-methylsulfinyl-pyrimidin-4-yl)-1H-indole | HCID 67434315 | 94.9% |
반응 단계
To a solution of 4-bromo-1-(2-methylsulfanyl-pyrimidin-4-yl)-1H-indole (5.0 g) in DCM (200 mL) at 0° C. was added MCPBA (4.01 g) in portions, and the mixture stirred at 0° C. for 1 h. The reaction mixture was quenched in 10% Na2SO3 (aq), partitioned between DCM and NaHCO3 (aq), the organic layer washed with NaHCO3 (aq), and dried over Na2SO4. The solvent was stripped to provide a light yellow solid, which was then treated with hot EtOAc/hexane (50:50), filtered, dried to provide 4-bromo-1-(2-methylsulfinyl-pyrimidin-4-yl)-1H-indole (4.98 g) as an off-white powder.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08227478B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_07 |
|---|
| ORD ID | ord-6f950d9fb35a4e35a8c8a8470c1c5c25 |
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| 출처 메모 | uspto-grants-2012_07 |
|---|
