2,3-Dihydrobenzo(b)furan-5-carboxylic acid → 2,3-Dihydro-benzofuran-5-carboxylic acid {2-methyl-4-[3-(2-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-phenyl}-amide

HRID 1516546Notes

Reaction equation

HRID 1516546 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][CH:10]([CH2:13][N:14]3[CH2:18][CH2:17][CH2:16][CH:15]3[CH3:19])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[NH2:20].[O:21]1[C:25]2[CH:26]=[CH:27][C:28]([C:30](O)=[O:31])=[CH:29][C:24]=2[CH2:23][CH2:22]1>>[CH3:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][CH:10]([CH2:13][N:14]3[CH2:18][CH2:17][CH2:16][CH:15]3[CH3:19])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[NH:20][C:30]([C:28]1[CH:27]=[CH:26][C:25]2[O:21][CH2:22][CH2:23][C:24]=2[CH:29]=1)=[O:31]

Participants

3

Reactant 2

HCID 6765832,3-Dihydrobenzo(b)furan-5-carboxylic acidHCID 684676422-Methyl-4-[3-(2-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-phenylamine

Product 1

HCID 252637192,3-Dihydro-benzofuran-5-carboxylic acid {2-methyl-4-[3-(2-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-phenyl}-amide

Procedure

The title compound was prepared in a manner substantially the same as Example 1 by coupling 2-methyl-4-[3-(2-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-phenylamine with 2,3-dihydro-benzofuran-5-carboxylic acid. MS: 420.3 (M+H).

Sources & evidence

ORD record
ord-a702b857bf38477999a1b30b3fa7192e
Source dataset
uspto-grants-2012_07
Patent number
US08227504B2

Reaction notes

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