反应详情

温度

101 °C

4-(3-Fluoro-benzyloxy)-phenylamine (31.2 g, 144 mmol) was dissolved in toluene (208 mL) and acetic acid (52 mL). Itaconic acid (18.96 g, 144 mmol) was added to the stirred mixture. The mixture was heated to reflux (101° C.) and kept at this temperature for 3 h. On cooling, the product started to crystallize. At 10° C., heptane (125 mL) was added to the suspension which was stirred 1 h at 0° C. and filtered. The crystals were washed with toluene/heptane 1:1 and with heptane and dried in vacuo to afford the crude product (43.2 g). The crude product was purified by treatment with hot isopropyl acetate to give rac-1-[4-(3-fluoro-benzyloxy)-phenyl]-5-oxo-pyrrolidine-3-carboxylic acid (40.5 g, 86%; HPLC: 99.2% area), m.p. 148-149° C. (uncorr.).

1. temperatureThe mixture was heated
2. temperatureOn cooling
3. customto crystallize
4. additionAt 10° C., heptane (125 mL) was added to the suspension which
5. filtrationfiltered
6. washThe crystals were washed with toluene/heptane 1:1 and with heptane
7. customdried in vacuo
8. customto afford the crude product (43.2 g)
9. customThe crude product was purified by treatment with hot isopropyl acetate