反应详情

Under argon, 3.3 g (11 mmol) of the mixture of 7-cyclopent-2-en-1-yl-5-methoxy-2,2-dimethyl-4-oxochroman-6-carbaldehyde and 7-cyclopent-3-en-1-yl-5-methoxy-2,2-dimethyl-4-oxochroman-6-carbaldehyde (Example 4A/5A) are dissolved in 200 ml of ethyl acetate, 500 mg of palladium-on-carbon (10%) are added and hydrogen gas is charged at room temperature under atmospheric pressure. After one hour, the mixture is filtered through a layer of silica gel, the filter cake is washed thoroughly with ethyl acetate and the filtrate is concentrated. This gives 3.3 g (99% of theory) of the title compound.

1. filtrationthe mixture is filtered through a layer of silica gel
2. washthe filter cake is washed thoroughly with ethyl acetate
3. concentrationthe filtrate is concentrated