Iodine chloride → HCID 490385, compound

HRID 1516768Notes

Reaction equation

HRID 1516768 reaction equation
ICl.[OH:3][CH2:4]C(CO)OCN1C=C(C=C)C(=O)NC1=O.[OH:20][CH2:21][CH2:22][O:23][CH2:24][N:25]1[CH:32]=[C:31]([CH:33]([N:36]=[N+:37]=[N-:38])[CH2:34][I:35])[C:29](=[O:30])[NH:28][C:26]1=[O:27]>C(Cl)(Cl)Cl.CO>[OH:20][CH2:21][CH:22]([CH2:4][OH:3])[O:23][CH2:24][N:25]1[CH:32]=[C:31]([CH:33]([N:36]=[N+:37]=[N-:38])[CH2:34][I:35])[C:29](=[O:30])[NH:28][C:26]1=[O:27]

Participants

5

Reactant 3

HCID 24640Iodine chlorideHCID 490382HCID 490382, compoundHCID 10331953HCID 10331953, compound

Product 1

HCID 490385HCID 490385, compoundYield 29.6%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

Reaction of iodine monochloride (72.0 mg, 0.44 mmol) with 9a (95 mg, 0.39 mmol), using the procedure described for the preparation of 2c, and purification of the product by silica gel column chromatography using chloroform-methanol (90:10, v/v) as eluent afforded 10c as a syrup (48 mg, 29.6%).

Sources & evidence

ORD record
ord-79dd2417fa3e447b8082a52ac75d3f09
Source dataset
uspto-grants-2012_07
Patent number
US08227594B2

Reaction notes

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