N'-(1-benzyl-4-methyl-5-nitro-6-oxopyrimidin-2-yl)-N,N-dimethylmethanimidamide → N'-[1-benzyl-4-[(E)-2-(dimethylamino)ethenyl]-5-nitro-6-oxopyrimidin-2-yl]-N,N-dimethylmethanimidamide

HRID 1516834Notes

Reaction equation

[CH2:1]([N:8]1[C:13](=[O:14])[C:12]([N+:15]([O-:17])=[O:16])=[C:11]([CH3:18])[N:10]=[C:9]1/[N:19]=[CH:20]/[N:21]([CH3:23])[CH3:22])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CN(C=O)C>[CH2:1]([N:8]1[C:13](=[O:14])[C:12]([N+:15]([O-:17])=[O:16])=[C:11](/[CH:18]=[CH:1]/[N:8]([CH3:13])[CH3:9])[N:10]=[C:9]1/[N:19]=[CH:20]/[N:21]([CH3:22])[CH3:23])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

Conditions

Temperature: 65 °C

Procedure

To a solution of (E)-N′(1-benzyl-4-methyl-5-nitro-6-oxo-1,6-dihydropyrimidin-2-yl)-N,N-dimethylformimidamide (64.7 g, 0.2 mol) in DMF (254 mL) was added DMF-dimethylacetal (54.5 mL, 0.41 mol). The reaction mixture was stirred for 3 h at 65° C., cooled, and the solvent was removed under reduced pressure. The residue was triturated with ethanol, and the solid was collected by vacuum filtration (69.2 g, 91%) and used in the next step without further purification.

Workup

temperaturecooled
customthe solvent was removed under reduced pressure
customThe residue was triturated with ethanol
filtrationthe solid was collected by vacuum filtration (69.2 g, 91%)
customused in the next step without further purification

Sources & evidence

ORD record: ord-fbf38190112b4f2c9343b38e4a117a90
Source dataset: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08227601B2

Reaction notes

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