反应详情

温度

65 °C

To a solution of (E)-N′(1-benzyl-4-methyl-5-nitro-6-oxo-1,6-dihydropyrimidin-2-yl)-N,N-dimethylformimidamide (64.7 g, 0.2 mol) in DMF (254 mL) was added DMF-dimethylacetal (54.5 mL, 0.41 mol). The reaction mixture was stirred for 3 h at 65° C., cooled, and the solvent was removed under reduced pressure. The residue was triturated with ethanol, and the solid was collected by vacuum filtration (69.2 g, 91%) and used in the next step without further purification.

1. temperaturecooled
2. customthe solvent was removed under reduced pressure
3. customThe residue was triturated with ethanol
4. filtrationthe solid was collected by vacuum filtration (69.2 g, 91%)
5. customused in the next step without further purification