1-(benzo[d][1,3]dioxol-5-yl)-N-(5-(hydroxy(2-methoxyphenyl)methyl)pyridin-2-yl)cyclopropanecarboxamide → 1-(Benzo[d][1,3]dioxol-5-yl)-N-(5-((2-methoxyphenyl)(propoxy)methyl)pyridin-2-yl)cyclopropanecarboxamide

HRID 1516917Notes

Reaction equation

HRID 1516917 reaction equation
O1C2C=CC(C3(C(NC4C=CC(C(O)C5C=CC=CC=5OC)=CN=4)=O)CC3)=CC=2OC1.[O:32]1[C:36]2[CH:37]=[CH:38][C:39]([C:41]3([C:44]([NH:46][C:47]4[CH:52]=[CH:51][C:50]([CH:53]([O:62][CH2:63][CH2:64][CH2:65]O)[C:54]5[CH:59]=[CH:58][CH:57]=[CH:56][C:55]=5[O:60][CH3:61])=[CH:49][N:48]=4)=[O:45])[CH2:43][CH2:42]3)=[CH:40][C:35]=2[O:34][CH2:33]1>C(O)CC>[O:32]1[C:36]2[CH:37]=[CH:38][C:39]([C:41]3([C:44]([NH:46][C:47]4[CH:52]=[CH:51][C:50]([CH:53]([C:54]5[CH:59]=[CH:58][CH:57]=[CH:56][C:55]=5[O:60][CH3:61])[O:62][CH2:63][CH2:64][CH3:65])=[CH:49][N:48]=4)=[O:45])[CH2:43][CH2:42]3)=[CH:40][C:35]=2[O:34][CH2:33]1

Participants

4

Reactant 2

HCID 442365991-(benzo[d][1,3]dioxol-5-yl)-N-(5-(hydroxy(2-methoxyphenyl)methyl)pyridin-2-yl)cyclopropanecarboxamideHCID 442367041-(benzo[d][1,3]dioxol-5-yl)-N-(5-((3-hydroxypropoxy)(2-methoxyphenyl)methyl)pyridin-2-yl)cyclopropanecarboxamide

Product 1

HCID 442365641-(Benzo[d][1,3]dioxol-5-yl)-N-(5-((2-methoxyphenyl)(propoxy)methyl)pyridin-2-yl)cyclopropanecarboxamide

Reagents, catalysts & solvents 1

HCID 10311-PropanolSolvent

Procedure

1-(Benzo[d][1,3]dioxol-5-yl)-N-(5-((2-methoxyphenyl)(propoxy)methyl)pyridin-2-yl)cyclopropanecarboxamide was prepared from 1-(benzo[d][1,3]dioxol-5-yl)-N-(5-(hydroxy(2-methoxyphenyl)methyl)pyridin-2-yl)cyclopropanecarboxamide and propan-1-ol in a manner analogous to that of 1-(benzo[d][1,3]dioxol-5-yl)-N-(5-((3-hydroxypropoxy)(2-methoxyphenyl)methyl)pyridin-2-yl)cyclopropanecarboxamide.

Sources & evidence

ORD record
ord-c38b282abe9c4043becc63ef73153c00
Source dataset
uspto-grants-2012_07
Patent number
US08227615B2

Reaction notes

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