Trifluoroacetic acid → HCID 57441152, compound

HRID 1517087Notes

Reaction equation

COC1C=CC(C[NH:8][C:9]2[C:14]([C:15]([N:17]3[CH2:22][CH2:21][CH:20]([N:23]4[CH2:27][CH2:26][CH2:25][CH2:24]4)[CH2:19][CH2:18]3)=[O:16])=[C:13]([CH3:28])[CH:12]=[C:11]([C:29]3[CH:34]=[CH:33][CH:32]=[C:31]([C:35]([F:38])([F:37])[F:36])[CH:30]=3)[N:10]=2)=CC=1.FC(F)(F)C(O)=O>>[NH2:8][C:9]1[C:14]([C:15]([N:17]2[CH2:22][CH2:21][CH:20]([N:23]3[CH2:27][CH2:26][CH2:25][CH2:24]3)[CH2:19][CH2:18]2)=[O:16])=[C:13]([CH3:28])[CH:12]=[C:11]([C:29]2[CH:34]=[CH:33][CH:32]=[C:31]([C:35]([F:38])([F:37])[F:36])[CH:30]=2)[N:10]=1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 58016713HCID 58016713, compound

Product 1

HCID 57441152HCID 57441152, compound

Procedure

In analogy to the procedure described for the preparation of example 7, [2-(4-methoxy-benzylamino)-4-methyl-6-(3-trifluoromethyl-phenyl)-pyridin-3-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone (example 18) was reacted with trifluoroacetic acid to give the title compound as light yellow solid. MS: 433.5 (MH+).

Sources & evidence

ORD record: ord-10b7cf23a3844310968eb6a2ad900160
Source dataset: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08227613B2

Reaction notes

Loading…