Hydrochloric Acid → HCID 86611570, compound

HRID 1517169Notes

Reaction equation

HRID 1517169 reaction equation
C([O:5][C:6](=[O:56])[CH:7]([N:11]([CH2:23][C:24]1[CH:29]=[CH:28][C:27]([C:30](=[O:55])[NH:31][CH2:32][CH2:33][CH:34]([CH2:45][CH2:46][NH:47][C:48]([CH3:54])([CH3:53])[C:49](=[N:51][OH:52])[CH3:50])[CH2:35][CH2:36][NH:37][C:38]([CH3:44])([CH3:43])[C:39](=[N:41][OH:42])[CH3:40])=[CH:26][CH:25]=1)[S:12]([C:15]1[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=1)(=[O:14])=[O:13])[CH:8]([CH3:10])[CH3:9])(C)(C)C.Cl>ClCCl>[OH:52][N:51]=[C:49]([CH3:50])[C:48]([NH:47][CH2:46][CH2:45][CH:34]([CH2:35][CH2:36][NH:37][C:38]([CH3:43])([CH3:44])[C:39](=[N:41][OH:42])[CH3:40])[CH2:33][CH2:32][NH:31][C:30]([C:27]1[CH:26]=[CH:25][C:24]([CH2:23][N:11]([S:12]([C:15]2[CH:16]=[CH:17][C:18]([O:21][CH3:22])=[CH:19][CH:20]=2)(=[O:13])=[O:14])[CH:7]([CH:8]([CH3:10])[CH3:9])[C:6]([OH:56])=[O:5])=[CH:29][CH:28]=1)=[O:55])([CH3:54])[CH3:53]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86611571HCID 86611571, compound

Product 1

HCID 86611570HCID 86611570, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Dichloromethane (4 ml) was added to the tert-butyl ester (Compound 9*) (64 mg, 0.08 mmol) and to the milky coloured solution which was obtained at ambient temperature was bobbled hydrochloric acid gas for 10 minutes. The mixture was evaporated to dryness and the residue was co-evaporated with dichloromethane (5×5 ml) to afford the product as off-white solid. Yield 58 mg (97%). M+1=747.

Workup

  1. customwas obtained at ambient temperature
  2. customfor 10 minutes
  3. customThe mixture was evaporated to dryness

Sources & evidence

ORD record
ord-0395c8c32d1b4984b4caf315320e4cc5
Source dataset
uspto-grants-2012_07
Patent number
US08231858B2

Reaction notes

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