Hydrochloric Acid → HCID 86611573, compound

HRID 1517171Notes

Reaction equation

HRID 1517171 reaction equation
C([O:5][C:6](=[O:53])[CH:7]([N:11]([CH2:23][C:24]1[CH:29]=[CH:28][C:27]([C:30](=[O:52])[NH:31][CH2:32][CH2:33][O:34][CH2:35][CH2:36][O:37][CH2:38][CH2:39][O:40][CH2:41][CH2:42][NH:43][C:44](=[O:51])[CH2:45][CH2:46][CH2:47][C:48]([OH:50])=[O:49])=[CH:26][CH:25]=1)[S:12]([C:15]1[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=1)(=[O:14])=[O:13])[CH:8]([CH3:10])[CH3:9])(C)(C)C.Cl>ClCCl>[C:48]([CH2:47][CH2:46][CH2:45][C:44]([NH:43][CH2:42][CH2:41][O:40][CH2:39][CH2:38][O:37][CH2:36][CH2:35][O:34][CH2:33][CH2:32][NH:31][C:30]([C:27]1[CH:28]=[CH:29][C:24]([CH2:23][N:11]([S:12]([C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)(=[O:13])=[O:14])[CH:7]([CH:8]([CH3:10])[CH3:9])[C:6]([OH:53])=[O:5])=[CH:25][CH:26]=1)=[O:52])=[O:51])([OH:50])=[O:49]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86611574HCID 86611574, compound

Product 1

HCID 86611573HCID 86611573, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Dichloromethane (5 ml) was added to the tert-butyl ester (Compound 14*; 50 mg, 0.046 mmol) and to the milky coloured solution which was obtained at ambient temperature was bobbled hydrochloric acid gas for 10 minutes. The mixture was evaporated to dryness and the residue was co-evaporated with dichloromethane (5×5 ml) to afford the product as white solid. Yield 47 mg (99%). M+1=1035.

Workup

  1. customwas obtained at ambient temperature
  2. customfor 10 minutes
  3. customThe mixture was evaporated to dryness

Sources & evidence

ORD record
ord-3790c3d11a3444f2a02b9d7af36130da
Source dataset
uspto-grants-2012_07
Patent number
US08231858B2

Reaction notes

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