反应详情

温度

120 °C

11.65 g (37 mM) of N-[4-(2-bromopropanoyl)-2-nitrophenyl]acetamide dissolved in aqueous 47% hydrobromic acid solution are maintained at 120° C. for 15 minutes with stirring. The reaction medium is then poured into water and extracted with ethyl acetate. The organic phase is washed with water, with aqueous sodium hydrogen carbonate solution and finally with saturated aqueous sodium chloride solution. The organic phase is separated out by settling, dried over anhydrous sodium sulfate and then evaporated under vacuum to give 35.7 g of 1-(4-amino-3-nitrophenyl)-2-bromopropan-1-one in the form of a yellow solid.

1. extractionextracted with ethyl acetate
2. washThe organic phase is washed with water, with aqueous sodium hydrogen carbonate solution and finally with saturated aqueous sodium chloride solution
3. customThe organic phase is separated out
4. dry with materialdried over anhydrous sodium sulfate
5. customevaporated under vacuum