Potassium Carbonate → 1-(2-Chloroethyl)-4-methylpiperazine

HRID 1517200Notes

Reaction equation

HRID 1517200 reaction equation
Cl.Cl.[CH3:3][N:4]1[CH2:9][CH2:8][N:7]([CH2:10][CH2:11][Cl:12])[CH2:6][CH2:5]1.C(=O)([O-])[O-].[K+].[K+]>CCOCC>[CH3:3][N:4]1[CH2:9][CH2:8][N:7]([CH2:10][CH2:11][Cl:12])[CH2:6][CH2:5]1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 111839401-(2-Chloroethyl)-4-methylpiperazine dihydrochloride

Product 1

HCID 4137911-(2-Chloroethyl)-4-methylpiperazineYield 84%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The N′-methyl-N-2-chloroethylpiperazine dihydrochloride (10.0 g, 45.4 mmol) was added slowly to a mixture of 50% aqueous potassium carbonate (200 mL) and ether (200 mL) and the mixture was stirred for 30 min., layers were separated, aqueous layer extracted with ether ( 2×200 mL). Combined organic extracts were dried on anhydrous sodium sulfate and concentrated to give N′-methyl-N-2-chloroethylpiperazine (6.2 g).

Workup

  1. customlayers were separated
  2. extractionaqueous layer extracted with ether ( 2×200 mL)
  3. dry with materialCombined organic extracts were dried on anhydrous sodium sulfate
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-2b8cef406bd24c528ceff26668d3947d
Source dataset
uspto-grants-2012_07
Patent number
US08232277B2

Reaction notes

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