反应详情

Potassium-tert-butoxide (7.76 g, 69.2 mmol) and propionitrile (4.84 mL, 69.2 mmol) was added to a solution of 4-cyano-benzoic acid methyl ester (11.15 g, 69.2 mmol) in tetrahydrofuran (100 mL). This mixture was stirred at room temperature for 16 hours, and then quenched onto an aqueous 10% solution (weight/volume) citric acid (100 mL). The organic layer was separated and the aqueous layer was extracted with ethyl acetate (3×100 mL). The combined organic extracts were dried over magnesium sulphate, filtered, and evaporated under reduced pressure. This crude residue was triturated with tert-butyl methyl ether to give the title compound as a solid (7.00 g, 55%). 1H NMR (400 MHz, CDCl3): δ 1.65 (d, 3H), 4.35 (m, 1H), 7.85 (d, 2H), 8.10 (d, 2H).

1. customquenched onto an aqueous 10% solution (weight/volume) citric acid (100 mL)
2. customThe organic layer was separated
3. extractionthe aqueous layer was extracted with ethyl acetate (3×100 mL)
4. dry with materialThe combined organic extracts were dried over magnesium sulphate
5. filtrationfiltered
6. customevaporated under reduced pressure
7. customThis crude residue was triturated with tert-butyl methyl ether