反应详情

温度

100 °C

40 mg 2,6-dichloro-N-(4-chloro-3-(2-(2-(dimethylamino)ethylamino)-8-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl)-isonicotinamide and 50 μl diethylamine were dissolved in 5 ml DMSO and heated at 100° C. in the microwave for 10 min. Addition of further diethylamine and heating in the microwave was repeated multiple times until the reaction was complete. The reaction mixture was purified on HPLC-MS in MeCN/water (1% formic acid) to yield 23 mg.

1. temperatureheating in the microwave
2. customThe reaction mixture was purified on HPLC-MS in MeCN/water (1% formic acid)
3. customto yield 23 mg