4-Toluenesulfonyl chloride → N-(3-amino-propyl)-N-[(R)-1-(7-chloro-4-oxo-3-phenylamino-3,4-dihydro-quinazolin-2-yl)-but-3-ynyl]-4-methyl-benzenesulfonamide

HRID 1517352Notes

Reaction equation

HRID 1517352 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:38])[N:7]([NH:31][C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[C:8]([C@H:12]([NH:16][CH2:17][CH2:18][CH2:19][N:20]3C(=O)C4C(=CC=CC=4)C3=O)[CH2:13][C:14]#[CH:15])=[N:9]2)=[CH:4][CH:3]=1.S(Cl)(Cl)(=O)=O.[CH3:44][C:45]1[CH:50]=[CH:49][C:48]([S:51](Cl)(=[O:53])=[O:52])=[CH:47][CH:46]=1>N1C=CC=CC=1.CC(N(C)C)=O.C(C#N)(C)=O>[NH2:20][CH2:19][CH2:18][CH2:17][N:16]([C@@H:12]([C:8]1[N:7]([NH:31][C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[C:6](=[O:38])[C:5]2[C:10](=[CH:11][C:2]([Cl:1])=[CH:3][CH:4]=2)[N:9]=1)[CH2:13][C:14]#[CH:15])[S:51]([C:48]1[CH:49]=[CH:50][C:45]([CH3:44])=[CH:46][CH:47]=1)(=[O:53])=[O:52]

Participants

6

Reactant 3

HCID 73974-Toluenesulfonyl chlorideHCID 24648Sulfuryl chlorideHCID 57695432(R)-2-{3-[1-(7-chloro-4-oxo-3-phenylamino-3,4-dihydro-quinazolin-2-yl)-but-3-ynylamino]-propyl}-isoindole-1,3-dione

Product 1

HCID 25151810N-(3-amino-propyl)-N-[(R)-1-(7-chloro-4-oxo-3-phenylamino-3,4-dihydro-quinazolin-2-yl)-but-3-ynyl]-4-methyl-benzenesulfonamide

Reagents, catalysts & solvents 2

HCID 1049PyridineSolventHCID 131729853DMA AcCNSolvent

Conditions

Temperature
45 °C

Procedure

A solution of 2-{3-[(R)-1-(7-chloro-4-oxo-3-phenylamino-3,4-dihydro-quinazolin-2-yl)-but-3-ynylamino]-propyl}-isoindole-1,3-dione (52.6 mg, 0.10 μmol) in pyridine (0.5 mL) was treated with respective sulfonyl chloride (in this case 4-methyl benzenesulfonyl chloride, 0.25M solution in DMA/AcCN (1:1), 0.5 mL, 0.125 μmol). The mixture was stirred at 45° C. for 24 h. Solvent was removed under reduced pressure. Residue was taken in MeOH (1.0 mL) and treated with hydrazine (0.25 mL). Reaction mixture was stirred at room temperature for 16 h and solvent removed under reduced pressure. The product was purified with reverse phase chromatography to give final product. Yield (10.4 mg, 20%). LCMS: m/e 551 [M+H].

Workup

  1. customSolvent was removed under reduced pressure
  2. additiontreated with hydrazine (0.25 mL)
  3. customReaction mixture
  4. stirringwas stirred at room temperature for 16 h
  5. customsolvent removed under reduced pressure
  6. customThe product was purified with reverse phase chromatography

Sources & evidence

ORD record
ord-fefdecdfb0fc44b1a68533e8dddc6f3b
Source dataset
uspto-grants-2012_07
Patent number
US08232285B2

Reaction notes

Loading…