Trifluoroacetic acid → HCID 86645318, compound

HRID 1517374Notes

Reaction equation

HRID 1517374 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[CH2:11][C:10]3([CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]3)[O:9][N:8]=2)=[CH:3][CH:2]=1.[F:24][C:25]([F:30])([F:29])[C:26]([OH:28])=[O:27]>C(Cl)Cl>[F:24][C:25]([F:30])([F:29])[C:26]([OH:28])=[O:27].[F:24][C:25]([F:30])([F:29])[C:26]([OH:28])=[O:27].[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[CH2:11][C:10]3([CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)[O:9][N:8]=2)=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86645319HCID 86645319, compound

Product 1

HCID 86645318HCID 86645318, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-Butyl 3-(pyridin-4-yl)-1-oxa-2,8-diazaspiro[4.5]dec-2-ene-8-carboxylate (0.48 g, 1.5 mmol) was dissolved in methylene chloride (10 ml), the solution was cooled and trifluoroacetic acid (1.2 ml, 15 mmol) was slowly added. After refluxing for 2 h, the solvent was removed in vacuo and the residue was co-evaporated with 30 ml each of toluene and methanol. Yield: 0.74 g (100%)

Workup

  1. temperaturethe solution was cooled
  2. temperatureAfter refluxing for 2 h
  3. customthe solvent was removed in vacuo

Sources & evidence

ORD record
ord-ada6120cb33349b390f2c6fd262ff992
Source dataset
uspto-grants-2012_07
Patent number
US08232288B2

Reaction notes

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