Trifluoroacetic acid → HCID 178483008, compound

HRID 1517382Notes

Reaction equation

HRID 1517382 reaction equation
C(O)(C(F)(F)F)=O.C(O[N:13]([CH2:17][C:18]1[NH:22][C:21]2[CH:23]=[CH:24][CH:25]=[C:26]([C:27]([O:29][CH3:30])=[O:28])[C:20]=2[N:19]=1)[CH:14]=C=O)(C)(C)C>C(Cl)Cl>[CH3:14][NH:13][CH2:17][C:18]1[NH:19][C:20]2[C:26]([C:27]([O:29][CH3:30])=[O:28])=[CH:25][CH:24]=[CH:23][C:21]=2[N:22]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86649681methyl 2-((tert-butoxy-carbonyl(methyl)amino)methyl)-1H-benzo[d]imidazole-4-carboxylate

Product 1

HCID 178483008HCID 178483008, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

TFA (15 ml) was added to a cooled solution (0° C.) of methyl 2-((tert-butoxy-carbonyl(methyl)amino)methyl)-1H-benzo[d]imidazole-4-carboxylate (12.54 mmol) in methylene chloride (60 ml) and the reaction mixture was stirred at room temperature for 2 h. The solvent was evaporated off completely, in vacuo, and the residue was co-distilled 2× with methylene chloride and employed in the next stage.

Workup

  1. customThe solvent was evaporated off completely

Sources & evidence

ORD record
ord-cc725669356c4d7db424584d3b20cca2
Source dataset
uspto-grants-2012_07
Patent number
US08232288B2

Reaction notes

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