Morpholine → 6-Chloro-4-(morpholin-4-yl)pyrido[3,2-d]pyrimidine

HRID 1517404Notes

Reaction equation

Cl[C:2]1[C:3]2[N:11]=[C:10]([Cl:12])[CH:9]=[CH:8][C:4]=2[N:5]=[CH:6][N:7]=1.[NH:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1>>[O:16]1[CH2:17][CH2:18][N:13]([C:2]2[C:3]3[N:11]=[C:10]([Cl:12])[CH:9]=[CH:8][C:4]=3[N:5]=[CH:6][N:7]=2)[CH2:14][CH2:15]1

Participants

Reactant 2

HCID 8083Morpholine

HCID 105841654,6-Dichloropyrido[3,2-d]pyrimidine

Product 1

HCID 714076986-Chloro-4-(morpholin-4-yl)pyrido[3,2-d]pyrimidineYield 71%

Procedure

The title compound was synthesized in 71% yield from 4,6-dichloro-pyrido[3,2-d]pyrimidine and morpholine by the procedure of example 65, and was characterized by its mass spectrum as follows: MS (m/z): 251.1 ([M+H]+, 100).

Sources & evidence

ORD record: ord-40e4627880354fa1bc8a8fe93a31816c
Source dataset: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08232278B2

Reaction notes

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