Potassium Carbonate → HCID 68912930, compound

HRID 1517431Notes

Reaction equation

HRID 1517431 reaction equation
C([NH:4][C:5]1[N:6]=[C:7]([N:25]2[CH2:31][CH2:30][CH2:29][NH:28][CH2:27][CH:26]2[C:32](=[O:41])[NH:33][C:34]2[CH:39]=[CH:38][CH:37]=[C:36]([CH3:40])[CH:35]=2)[C:8]2[N:14]=[C:13]([C:15]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[C:17]([O:23][CH3:24])[CH:16]=3)[CH:12]=[CH:11][C:9]=2[N:10]=1)(=O)C.C(=O)([O-])[O-].[K+].[K+]>CO.O>[NH2:4][C:5]1[N:6]=[C:7]([N:25]2[CH2:31][CH2:30][CH2:29][NH:28][CH2:27][CH:26]2[C:32](=[O:41])[NH:33][C:34]2[CH:39]=[CH:38][CH:37]=[C:36]([CH3:40])[CH:35]=2)[C:8]2[N:14]=[C:13]([C:15]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[C:17]([O:23][CH3:24])[CH:16]=3)[CH:12]=[CH:11][C:9]=2[N:10]=1

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 68917095HCID 68917095, compound

Product 1

HCID 68912930HCID 68912930, compoundYield 93%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A solution of 2-acetamido-4-[(N-3-methylphenylcarbamoyl)-homopiperazin-1-yl]-6-(3,4-dimethoxyphenyl)-pyrido[3,2-d]pyrimidine (110 mg, 0.24 mmol) and potassium carbonate (83 mg, 0.6 mmol) in methanol (10 ml) and water (5 ml) was heated at 50° C. for 2 hours. The solvents were evaporated in vacuo and the crude residue was purified by silica gel flash chromatography, the mobile phase being a MeOH/CH2Cl2 mixture in a volume ratio of 1:30, resulting in the pure title compound (96 mg, yield: 93%) which was characterised as follows:

Workup

  1. customThe solvents were evaporated in vacuo
  2. customthe crude residue was purified by silica gel flash chromatography

Sources & evidence

ORD record
ord-f02bd4b59c564a75a8aeea0988b7cad5
Source dataset
uspto-grants-2012_07
Patent number
US08232278B2

Reaction notes

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