Glycol monoethyl ether → N-[6-Chloro-4-(2-ethoxyethoxy)pyrido[3,2-d]pyrimidin-2-yl]acetamide

HRID 1517432Notes

Reaction equation

HRID 1517432 reaction equation
[C:1]([NH:4][C:5]1[NH:6][C:7](=[O:16])[C:8]2[N:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:9]=2[N:10]=1)(=[O:3])[CH3:2].[CH2:17]([O:19][CH2:20][CH2:21]O)[CH3:18]>>[C:1]([NH:4][C:5]1[N:6]=[C:7]([O:16][CH2:18][CH2:17][O:19][CH2:20][CH3:21])[C:8]2[N:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:9]=2[N:10]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 8076Glycol monoethyl etherHCID 135978119N-(6-Chloro-4-oxo-1,4-dihydropyrido[3,2-d]pyrimidin-2-yl)acetamide

Product 1

HCID 71428444N-[6-Chloro-4-(2-ethoxyethoxy)pyrido[3,2-d]pyrimidin-2-yl]acetamideYield 48.3%

Procedure

4 mmol 2-acetamido-6-chloro-pyrido[3,2-d]pyrimidin-4(3H)-one (0.954 g) was reacted with 6 mmol 2-ethoxyethanol (0.54 g) yielding the pure title compound (0.6 g, yield: 48%) which was characterised as follows:

Sources & evidence

ORD record
ord-150ad383a94b4cf790140d5b3177662f
Source dataset
uspto-grants-2012_07
Patent number
US08232278B2

Reaction notes

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