2-Methoxyethanol → HCID 86630379, compound

HRID 1517433Notes

Reaction equation

HRID 1517433 reaction equation
[C:1]([NH:4][C:5]1[NH:6][C:7](=[O:16])[C:8]2[N:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:9]=2[N:10]=1)(=[O:3])[CH3:2].[CH3:17][O:18][CH2:19][CH2:20]O>>[C:1]([NH:4][C:5]1[N:6]=[C:7]([O:16][CH2:20][CH2:19][O:18][CH3:17])[C:8]2[N:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:9]=2[N:10]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 80192-MethoxyethanolHCID 135978119N-(6-Chloro-4-oxo-1,4-dihydropyrido[3,2-d]pyrimidin-2-yl)acetamide

Product 1

HCID 86630379HCID 86630379, compoundYield 14%

Procedure

5 mmol 2-acetamido-6-chloro-pyrido[3,2-d]pyrimidin-4(3H)-one (1.2 g) was reacted with 7.5 mmol 2-methoxyethanol (0.54 g) to give the pure title compound (0.2 g, yield: 14%) which was characterised as follows:

Sources & evidence

ORD record
ord-bfada9b13ec54629ae0826644f2d64a6
Source dataset
uspto-grants-2012_07
Patent number
US08232278B2

Reaction notes

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