2-Methoxyethanol → 6-(4-Fluorophenyl)-4-(2-methoxyethoxy)pyrido[3,2-d]pyrimidine

HRID 1517445Notes

Reaction equation

Cl[C:2]1[C:3]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)[CH:9]=[CH:8][C:4]=2[N:5]=[CH:6][N:7]=1.O(C1C2N=C(C3C=CC(F)=CC=3)C=CC=2N=CN=1)C1C=CC=CC=1.[CH3:43][O:44][CH2:45][CH2:46][OH:47]>>[CH3:43][O:44][CH2:45][CH2:46][O:47][C:2]1[C:3]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)[CH:9]=[CH:8][C:4]=2[N:5]=[CH:6][N:7]=1

Participants

Reactant 3

HCID 80192-Methoxyethanol

HCID 576983476-(4-Fluorophenyl)-4-phenoxypyrido[3,2-d]pyrimidine

HCID 579067564-Chloro-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidine

Product 1

HCID 576983336-(4-Fluorophenyl)-4-(2-methoxyethoxy)pyrido[3,2-d]pyrimidineYield 78%

Procedure

was synthesized from 4-chloro-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine and 2-methoxyethanol in 78% yield, using the procedure described for the synthesis of 4-phenoxy-6-(4-fluorophenyl)-pyrido[3,2-d]pyrimidine The mass spectrum characterising data is as follows: MS (m/z): 300 ([M+H]+, 100).

Sources & evidence

ORD record: ord-84ebff27d16d4b87a5e78d7c8d1de6fe
Source dataset: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08232278B2

Reaction notes

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