3-Fluorophenylboronic acid → 3-Amino-6-(3-fluorophenyl)pyridine-2-carboxamide

HRID 1517448Notes

Reaction equation

HRID 1517448 reaction equation
[NH2:1][C:2]1[C:3]([C:9]([NH2:11])=[O:10])=[N:4][C:5](Cl)=[CH:6][CH:7]=1.[F:12][C:13]1[CH:14]=[C:15](B(O)O)[CH:16]=[CH:17][CH:18]=1.NC1C(C(N)=O)=NC(C2C=CC(F)=CC=2)=CC=1>>[NH2:1][C:2]1[C:3]([C:9]([NH2:11])=[O:10])=[N:4][C:5]([C:17]2[CH:16]=[CH:15][CH:14]=[C:13]([F:12])[CH:18]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 27339863-Fluorophenylboronic acidHCID 107497043-Amino-6-chloropyridine-2-carboxamideHCID 596479063-Amino-6-(4-fluorophenyl)picolinamide

Product 1

HCID 576983423-Amino-6-(3-fluorophenyl)pyridine-2-carboxamideYield 92%

Procedure

was synthesized from 3-amino-6-chloropyridine-2-carboxylic acid amide and 3-fluorophenylboronic acid in 92% yield as a white solid, using the procedure described for the synthesis of 3-amino-6-(4-fluorophenyl)-pyridine-2-carboxylic acid amide. The mass spectrum was as follows: MS (m/z): 232 ([M+H]+, 100).

Sources & evidence

ORD record
ord-bf4635dbfe234b77b14b1db52eea5732
Source dataset
uspto-grants-2012_07
Patent number
US08232278B2

Reaction notes

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