反应详情

A mixture of 3-amino-6-(3-fluorophenyl)-pyridine-2-carboxylic acid amide (0.46 g, 2.0 mmol) and triphosgene (0.30 g, 1.0 mmol) in dioxane (10 ml) was heated under reflux for 2 hours. After cooling to room temperature, the precipitate was collected by filtration and washed with diethyl ether. The title compound was obtained as a yellowish solid (410 mg, yield 80%) which was characterised as follows: MS (m/z): 258 ([M+H]+, 100).

1. temperaturewas heated
2. temperatureunder reflux for 2 hours
3. filtrationthe precipitate was collected by filtration
4. washwashed with diethyl ether