Dimethylformamide → 4-[2-(2-Chloro-ethoxy)-phenyl]-piperidine-1-carboxylic acid tert-butyl ester

HRID 151755Notes

Reaction equation

HRID 151755 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([c:14]2[c:15]([OH:20])[cH:16][cH:17][cH:18][cH:19]2)[CH2:12][CH2:13]1.[C:35](=[O:36])([O-:37])[O-:38].[Cl:21][CH2:22][CH2:23][O:24][S:25]([c:26]1[cH:27][cH:28][c:29]([CH3:30])[cH:31][cH:32]1)(=[O:33])=[O:34].[Cs+:39].[Cs+:40].[O:41]=[CH:42][N:43]([CH3:44])[CH3:45]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([c:14]2[c:15]([O:20][CH2:23][CH2:22][Cl:21])[cH:16][cH:17][cH:18][cH:19]2)[CH2:12][CH2:13]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 6639Ethanol, 2-chloro-, 1-(4-methylbenzenesulfonate)HCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 17174861Tert-butyl 4-(2-hydroxyphenyl)piperidine-1-carboxylate

Product 1

HCID 587127044-[2-(2-Chloro-ethoxy)-phenyl]-piperidine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-325014f5e5a94d039ce422a486ee8e0a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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