Hydrochloric Acid → HCID 58268546, compound

HRID 1517559Notes

Reaction equation

HRID 1517559 reaction equation
[F:1][C:2]1[S:6][C:5]2[C:7]3([O:20][CH2:21][C:22]([F:24])([F:23])[C:4]=2[CH:3]=1)[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][CH2:8]3.Cl>>[F:1][C:2]1[S:6][C:5]2[C:7]3([O:20][CH2:21][C:22]([F:23])([F:24])[C:4]=2[CH:3]=1)[CH2:8][CH2:9][NH:10][CH2:11][CH2:12]3

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 67168952HCID 67168952, compound

Product 1

HCID 58268546HCID 58268546, compoundYield 89.8%

Procedure

t-Butyl 2,4,4-trifluorospiro[5H-thieno[2,3-c]pyran-7,4′-piperidine]-1′-carboxylate (2.00 g, 5.50 mmol) is dissolved in hydrochloric acid (4N in dioxane) (10 mL, 40 mmol). The mixture is stirred at room temperature for 1 h and then passed through a 50 g SCX cartridge (solid cation exchange) to yield 1.3 g of the title compound after evaporation of 2 N ammonia in methanol fraction. MS (m/z): 264 (M+1).

Sources & evidence

ORD record
ord-4362d6413c4645fbabdac74497aa164f
Source dataset
uspto-grants-2012_07
Patent number
US08232289B2

Reaction notes

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