HCID 67168325, compound → HCID 58268550, compound

HRID 1517587Notes

Reaction equation

HRID 1517587 reaction equation
[CH3:1][O:2][CH2:3][C:4]1[C:5]([N:10]2[CH:14]=[C:13]([CH2:15][OH:16])[C:12]([CH3:17])=[N:11]2)=[N:6][CH:7]=[CH:8][CH:9]=1>ClCCl.[O-2].[Mn+4].[O-2]>[CH3:1][O:2][CH2:3][C:4]1[C:5]([N:10]2[CH:14]=[C:13]([CH:15]=[O:16])[C:12]([CH3:17])=[N:11]2)=[N:6][CH:7]=[CH:8][CH:9]=1

Participants

4

Reactant 1

HCID 67168325HCID 67168325, compound

Product 1

HCID 58268550HCID 58268550, compoundYield 82.8%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

A mixture of A mixture of [1-[3-(methoxymethyl)-2-pyridyl]-3-methyl-pyrazol-4-yl]methanol (2.2 g, 9.4 mmol) and manganese (IV) oxide (19 g, 188.8 mmol) is stirred in dichloromethane (20 mL) at room temperature overnight. The reaction mixture is filtered over celite and the solvent evaporated under reduced pressure to yield 1.8 g of the title compound that is used without further purification. MS (m/z): 232 (M+1).

Workup

  1. filtrationThe reaction mixture is filtered over celite
  2. customthe solvent evaporated under reduced pressure

Sources & evidence

ORD record
ord-19c98fe97d644d3498ac37774c0c08d0
Source dataset
uspto-grants-2012_07
Patent number
US08232289B2

Reaction notes

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