反应详情

A round-bottom flask containing 3-(2,5-dihydrofuran-2-yl)-2-fluoropyridine (170 mg, 1 mmol) and 10% Pd/C in methanol (3.1 mL) is evacuated under vacuum and filled with hydrogen with the aid of a balloon. The reaction is stirred overnight at room temperature and filtered over celite. The solvent is evaporated in vacuo to give 148 mg of 2-fluoro-3-(tetrahydrofuran-2-yl)pyridine. MS (m/z): 168 (M+1).

1. customis evacuated under vacuum
2. additionfilled with hydrogen with the aid of a balloon
3. filtrationfiltered over celite
4. customThe solvent is evaporated in vacuo